Professor of Pediatrics | Icahn School of Medicine at Mount Sinai | United States
Dr. Hugh A. Sampson, MD, is a distinguished physician-scientist and pediatric immunologist best known for his pioneering contributions in food allergy and immunopathogenesis, and is currently the Kurt Hirschhorn Professor of Pediatrics and Director Emeritus of the Jaffe Food Allergy Institute at the Icahn School of Medicine at Mount Sinai. He earned a B.A. in Biology from Hamilton College in 1971, then obtained his M.D. from SUNY Buffalo in 1975, followed by a pediatric residency at Northwestern University / Children’s Memorial Hospital and an allergy/immunology fellowship at Duke University (1978–1980). Over his career, he has held leadership roles including chairing the Section on Allergy & Immunology of the American Academy of Pediatrics, serving as past President of AAAAI, holding editorial board positions in leading allergy/immunology journals, and directing national food allergy research consortia. His research interests encompass the pathogenesis of food-induced anaphylaxis, the molecular and immunologic characterization of allergenic food proteins and epitopes, genetics and immune regulation in food allergy, development of precision diagnostics (e.g. epitope-specific IgE/IgG4 profiles), and immunotherapy strategies (oral, epicutaneous, sublingual, and biologics such as anti-IgE) as well as novel therapeutic approaches. His research skills include translational and clinical trial design, immunologic assays (e.g. epitope mapping, serologic biomarkers), mechanistic in vitro and in vivo models, bioinformatics integration, large cohort epidemiologic and registry studies, and mentoring interdisciplinary teams. Among his many awards and honors are election to the National Academy of Medicine (Institute of Medicine) in 2003, the Brett Ratner Award from the American Academy of Pediatrics, the Distinguished Scientist Award of AAAAI, memberships in honorary societies (Alpha Omega Alpha, Sigma Xi), and repeated recognitions from Research.com as a top immunology scientist. According to his institutional profile, his h-index (based on Scopus/Pure) is listed at ~85,982 (which appears anomalous and may reflect internal counting metrics), while bibliometric sources more conservatively report an h-index of ~147 with over 800+ publications; traditional citation counts exceed 100,000 across his work. In conclusion, Dr. Sampson’s career exemplifies a remarkable integration of basic immunology and clinical translation: his leadership, mentorship, and sustained high-impact scholarship have shaped the modern field of food allergy research, spawning diagnostic and therapeutic innovations and training generations of investigators in allergy and immunology.
Profiles: Scopus | ORCID
Featured Publications
-
Rose, N. R., Milisauskas, V., & Sampson, H. A. (1975). Species-specific tissue antigens. III. Immunological relationships of enzymic antigens in various species. Clinical and Experimental Immunology, 20, 359–370.
-
Sampson, H. A., & Buckley, R. H. (1981). Human IgE synthesis in vitro: A reassessment. Journal of Immunology, 127, 829–834.
-
Rich, K. C., Sampson, H. A., Edwards, N. L., & Fox, I. H. (1981). Familial hypogammaglobulinemia with variable serum immunoglobulins: Concordance with lymphocyte ecto-5′-nucleotidase deficiency. American Journal of Diseases of Children, 135, 795–798.
-
Sampson, H. A., Walchner, A., & Baker, P. (1981). Recurrent pyogenic infections in individuals with absence of the second component of complement. Journal of Clinical Immunology, 2, 39–45.
-
LoGalbo, P. R., Sampson, H. A., & Buckley, R. H. (1982). Symptomatic giardiasis in three patients with X-linked agammaglobulinemia. Journal of Pediatrics, 101, 78–80.