Dr. Shinichiro Sawa | Medicine | Best Researcher Award

Professor | Kyushu University | Japan 

Dr. Shinichiro Sawa is a highly accomplished Japanese immunologist and medical researcher renowned for his pioneering work in immune regulation, autoimmunity, and inflammation. He currently serves as a Professor at the Institute of Bioregulation, Kyushu University, Japan, where he leads innovative studies in molecular and cellular immunology. Dr. Sawa began his academic journey at Osaka University, earning his Medical Degree (M.D.) in 2000 and subsequently his Ph.D. in Medicine in 2006 from the same institution, where he developed a strong foundation in biomedical sciences and experimental medicine. His professional trajectory includes significant academic roles as Assistant Professor at the University of Tokyo (2011–2016) and Associate Professor at Hokkaido University’s Institute for Genetic Medicine (2016–2018) before joining Kyushu University in 2019. Dr. Sawa’s research interests center on understanding how immune cells, such as γδ T cells, fibroblasts, and plasma cells, interact with tissue environments to regulate immune tolerance, autoimmunity, and inflammatory diseases. His studies, published in prestigious journals such as Nature Immunology, Journal of Clinical Investigation, and Journal of Investigative Dermatology, have shed light on how fibroblasts contribute to central immune tolerance and how plasma cells promote osteoclastogenesis in autoimmune arthritis. His research skills encompass cellular immunology, molecular signaling analysis, animal modeling of immune diseases, flow cytometry, and translational immunopathology, demonstrating both depth and precision in experimental design and interpretation. Recognized for his scientific contributions, Dr. Sawa has received numerous academic honors and research recognitions throughout his career, reflecting his influence in the global immunology community. In conclusion, Dr. Shinichiro Sawa stands as a leading figure in immunological research, bridging basic science and clinical application to advance our understanding of immune homeostasis and to pave the way for novel therapeutic strategies against autoimmune and inflammatory disorders.

Profiles: Scopus | ORCID

Featured Publications

1. Nonaka, D., Yoshida, S., Nakano, K., Li, X., Okamura, T., Umemoto, E., Yamada, T., Watanabe, M., Jinno, S., Ito, M., Tsuda, M., Noguchi, N., Jiang, X.-J., Sumiya, E., & Sawa, S. (2025). Fibroblast-derived CSF1 maintains colonization of gut mucosal macrophage to resist bacterial infection. Mucosal Immunology.

2. Onji, M., Sigl, V., Lendl, T., Novatchkova, M., Ullate-Agote, A., Andersson-Rolf, A., Kozieradzki, I., Koglgruber, R., Pai, T.-P., Lichtscheidl, D., Nayak, K., Zilbauer, M., Carranza García, N.-A., Sievers, L., Falk-Paulsen, M., Cronin, S. J. F., Hagelkruys, A., Sawa, S., Osborne, L. C., Rosenstiel, P., Pasparakis, M., Ruland, J., Takayanagi, H., Clevers, H., Koo, B.-H., & Penninger, J. M. (2025). RANK drives structured intestinal epithelial expansion during pregnancy. Nature, 637(8044), 156–166.

3. Nitta, T., Tsutsumi, M., Nitta, S., Muro, R., Suzuki, E. C., Nakano, K., Tomofuji, Y., Sawa, S., Okamura, T., Penninger, J. M., & Takayanagi, H. (2020). Fibroblasts as a source of self-antigens for central immune tolerance. Nature Immunology, 21(10), 1172–1180.

4. Nagashima, K., Sawa, S., Nitta, T., Tsutsumi, M., Okamura, T., Penninger, J. M., Nakashima, T., & Takayanagi, H. (2017). Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota. Nature Immunology, 18(6), 675–682.

5. Onder, L., Mörbe, U., Pikor, N., Novkovic, M., Cheng, H.-W., Hehlgans, T., Pfeffer, K., Becher, B., Waisman, A., Rülicke, T., Gommerman, J., Müller, C., Sawa, S., Scandella, E., & Ludewig, B. (2017). Lymphatic endothelial cells control initiation of lymph node organogenesis. Immunity, 47(1), 80–92.